Featured Posts from the ResearchGate Community
Research Blog is where featured posts from the ResearchGate community are aggregated to provide a reputable source for news, commentary, research, and innovation.
Goods-thinking versus Tree-thinking
In the famous Monty Python "Dead Parrot" sketch, John Cleese returns to a pet shop where he has just bought a parrot and asks for his money back. The reason being that the parrot is in fact dead. This seems to be a not unreasonable request on the p... Read more »
Revealing Sub-Optimality Conditions of Strategic Decisions
Introduction Fitness landscape theory is becoming to use for answering the search of developing species which desire to reach highest peak on the potential gene space in the field of evolutionary biology (Wright, 1932; Gillespie, 1984). Development o... Read more »
The Contribution of Knowledge of Virus Evolution for a Strategy of...
Most infectious diseases that have put heavy burdens on humans came from animal viruses. The examples of such influential diseases are the 1918 influenza pandemic, also known as the 'Spanish Flu' pandemic, that killed 20 – 50 million people worldwide... Read more »
In picture: Staurosporine as a probe in the kinase pockets
A 3D stereoscopic movie of a representative protein kinase in complex with staurosporine. The cyan, orange, and purple bar can be used to guide an inhibitor design based on staurosporine's prefered interaction. The figure above can be viewed on C... Read more »
Epigenetics in plants - considerations for the Risk Assessment of G...
GMOs - Risk Assessment During the 1990s the commercialization of transgenic plants started and the paradigm of a linear “one gene - one protein” was at the basis of the risk assessment. Regulation of genes is far more complex and epigenetic mechanism... Read more »
To what extent does the interspecies transmission in hemagglutinin...
The introduction of a strain of influenza virus A that has a new variety of the hemagglutinin gene to human population has been recorded in several outbreaks. The new hemagglutinin gene is typically acquired from other species, such as birds or swi... Read more »
Weekly Science Digest: Disasters, Determinism and Drains.
The 'Weekly Science Digest' is a compilation of science news from around the world. News suggestions are always welcome: mark.howardbanks@researchgate.net Scientists have come closer to understanding the plasticity of the brain after neuropsycholo... Read more »
Protease Mapping
Protease Mapping Purpose Tagged proteins are attached to a resin, and a partial protease digest is done. Unbound fragments are washed away, and the bound fragments are eluted and run on a gel. This method has many applications, including domain... Read more »
Immunofluorescence Protocol
Immunofluorescence Protocol Purpose Immunofluorescence is a technique used in genetic engineering to label antibodies or antigens with fluorescent dyes. Immunostaining is often used to visualize the subcellular distribution of biomolecules in flu... Read more »
Biotronics
Someone has truly said that 3 things are always changing, "Time, Temperature and Technology.” New technologies are the breathing a new life into this present Era. Very Small DNA is responsible for formation of giant Blue Whale. Every reaction, phys... Read more »
Synthetic Biology for Treatment of Cancer
Synthetic Biology is the growing technology and has various applications in different fields of science. Cancer treatment can be easier through this technology. There are many treatments for Cancer like Chemotherapy, Radiation therapy, anti Cancer Dr... Read more »
An introduction to the 'attractor' theory of gene regulatory networ...
Dr. HUANG Sui at the University of Calgary has spent the last few years exemplifying and improving the State Space & Attractor theory of gene regulatory networks (GRN), which was initially proposed by Prof. Stuart KAUFFMAN from 1960’s. Incorporat... Read more »
Dispersed element concentrations of rare elements in aquatic biodet...
It is the first time the concentrations of many elements were measured in the biodetritus that was formed in aquatic system under controlled conditions. The concentrations were found to decrease in the following order: Ca > Zn > Ba > Br > Ce > Se > Nd > La > U > Hf > Sb > Th > Sm > S > Cs > Au. Read more »
A rapid assay for mitochondrial DNA damage and respiratory chain in...
Human cells have two genomes. At the moment we are only testing new drugs for nuclear DNA damage. It is about time that we tested for mitochondrial genotoxicity as well. Read more »
Using X-ray luminiscence to overcome limitations in molecular imagi...
I thought of the possibility to use X-ray luminiscences to overcome limitations in molecular imaging 2.5 years ago and did not follow it because of negative colleague opinions, time and resource constraints, and now: it works and it is published - I will learn from this mistake! Read more »
Color CT Distinguishes Between Two Contrast Media
"Color" CT can be used to distinguish two different contrast media: in this case iodine and barium. Unfortunately this implementation is only currently being used in non-living mice - however, very interesting to read. Read more »
p32 & p53, twins with different fates
Fogal et al (2010) found that the p32 gene (on human chromosome 17q13.3), which was overexpressed in some cancer cells, had actually promoted the level of oxidative phosphorylation (OXPHOS) in mitochondria. The knockdown of p32 in an experiment then... Read more »
MicroRNA, trinucleotide repeats, and the genetics of general cognit...
A full understanding of the genetics of schizophrenia, autism, dyslexia, attention deficit hyperactivity disorder (ADHD), alzheimer and a large number of neurodegenerative diseases seems to be impossible without reckoning with IQ as a major confoundi... Read more »
Foreign body-induced granulation tissue: A novel source of adult st...
An inert foreign body placed in the subcutaneous tissue induces new tissue that encapsulates the foreign body (called granulation tissue). In a new study published in the journal Translational Research, Dr. Jilpa Patel and her group at the Cook Coun... Read more »
Evolution in Health and Medicine Sackler Colloquium: Stochastic epi...
Neo-Darwinian evolutionary theory is based on exquisite selection of phenotypes caused by small genetic variations, which is the basis of quantitative trait contribution to phenotype and disease. Here, we propose a new non-Lamarckian theory for a role of epigenetics in evolution. Read more »
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